Celli, Erramilli, and Bansil in the department of Physics at Boston University, Turner, Afdhal, Keates, Ghiran, and Kelly in Division of Gastroenterology at Beth Israsel Deaconess Medical Center and Harvard Medical School, Ewoldt and McKinley in Department of Mechanical Engineering, and So in Department of Biological Engineering at Massachusetts Institute of Technology in their study entitled “Helicobacter Pylori moves through mucus by reducing mucin viscoelasticity” (2009) find that H. Pylori has the ability to swim freely in gastric mucin by elevating pH- dependent rheology and reducing viscoelasticity. The research team provides evidence that H.pylori causes pH elevation by hydrolysis of urea through rheology studies using two-photon fluoresce microscopy. The purpose of this study is to understand the effects of H.pylori on gastric mucin as well as how H.pylori moves in the gastric mucin, so that we may learn more about H.pylori as a causative agent of gastric inflammation and H.pylori infections. The paper contributes a new finding about capability of H.pylori in the relationship with microbiological research as well as healthcare fields.
Citation: Celli JP, Turner BS, Afdhal NH, Keates S, Ghiran I, Kelly CP, Ewoldt RH, McKinley GH, So P, Erramilli S, Bansil R. 2009. Helicobacter pylori moves through mucus by reducing mucin viscoelasticity. Proceedings of the National Academy of Sciences. 06(34):14321-6.
