{"id":1118,"date":"2014-08-11T15:15:27","date_gmt":"2014-08-11T22:15:27","guid":{"rendered":"http:\/\/blogs.oregonstate.edu\/linuspaulinginstitute\/?p=1118"},"modified":"2016-05-16T16:57:59","modified_gmt":"2016-05-16T23:57:59","slug":"spending-time-circadian-rhythms","status":"publish","type":"post","link":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/2014\/08\/11\/spending-time-circadian-rhythms\/","title":{"rendered":"Spending time with circadian rhythms."},"content":{"rendered":"

\"sleeping<\/a><\/p>\n

 <\/p>\n

Our bodies change signals based on a\u00a0circadian clock\u00a0\u2013 stronger at certain times of the day and weaker at others.\u00a0It establishes a\u00a0rhythm of signals that influences our life.<\/p>\n

At least one-third of all genes in our bodies are affected by circadian\u00a0clocks, and so maintaining a normal\u00a0circadian rhythm is important to keep ourselves in good health. But many people fail to realize the impact that disrupting circadian rhythms has on our well-being.<\/p>\n

<\/b>\"circadian<\/p>\n

<\/b>When our circadian rhythms\u00a0are disrupted, our bodies have molecular sensors that tries to\u00a0adjust the timing of our internal clock and get us back on track. A good example is\u00a0recovery after\u00a0jet lag. After an initial exhaustion, your sleep patterns gradually become regular again \u2013 because its learning from cues in\u00a0your surroundings.<\/p>\n

What happens if we don\u2019t return to normal, if the entrainment doesn\u2019t have time to adapt due to constant disruptions, or if the clock and the rhythm are out of sync for different reasons? In general, this is considered a bad thing as it increases the risk for many chronic diseases.<\/p>\n

\"circadian<\/a>Circadian rhythms are often disrupted in older individuals, and this disruption can affect many aspects of cellular function (metabolism, repair, stress resistance, inflammation, and proliferation), although it is not yet clear why this occurs. Many researchers believe that this disruption may increase risk for chronic disease in older individuals.<\/p>\n

Is there anything we can do about this age-related disruption?<\/p>\n

Scientists at the Linus Pauling Institute have recently found that giving lipoic acid, a compound essential for cellular metabolism, to rodents helped to restore age-related changes in the circadian rhythms in the liver<\/a>. The liver has a special circadian clock, one that can be entrained by lipoic acid. This effect of lipoic acid on the liver could help explain many of its observed effects on metabolism.<\/p>\n

\"Lipoic-acid\"<\/a>Lipoic acid supplementation has previously been shown to enhance physical activity and memory in old animals and older adults, but it is unclear if these changes are all attributable to changes in the circadian clock. It is also unknown whether lipoic acid can affect circadian rhythms in other organs besides the liver.<\/p>\n

Further research is needed to determine if lipoic acid supplementation can effectively modulate circadian rhythms in humans and what the optimal supplemental intakes might be to improve overall health.<\/p>\n

For more information on the effects of lipoic acid on circadian rhythms, also see this study<\/a> from the Linus Pauling Institute.\u00a0And for more information on lipoic acid, see the Micronutrient Information Center<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

  Our bodies change signals based on a\u00a0circadian clock\u00a0\u2013 stronger at certain times of the day and weaker at others.\u00a0It establishes a\u00a0rhythm of signals that influences our life. At least one-third of all genes in our bodies are affected by circadian\u00a0clocks, and so maintaining a normal\u00a0circadian rhythm is important to keep ourselves in good health.… Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":5337,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[159207],"tags":[582818,582820,450219,582819],"class_list":["post-1118","post","type-post","status-publish","format-standard","hentry","category-feature-stories","tag-circadian","tag-clocks","tag-lipoic-acid","tag-rhythms"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack-related-posts":[{"id":1358,"url":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/2016\/02\/26\/diet-for-a-healthy-heart\/","url_meta":{"origin":1118,"position":0},"title":"Diet for a Healthy Heart","author":"Giana Angelo","date":"February 26, 2016","format":false,"excerpt":"You\u2019ve probably heard it before, but it\u2019s worth repeating: Heart disease is the leading cause of death for both men and women Diet and lifestyle choices can have a dramatic effect on the development of heart disease and other conditions affecting the cardiovascular system It\u2019s never too late to start\u2026","rel":"","context":"In "Ask the Expert"","block_context":{"text":"Ask the Expert","link":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/category\/ask-the-expert\/"},"img":{"alt_text":"A Healthy Heart of Fruits and Vegetables","src":"https:\/\/i0.wp.com\/blogs.oregonstate.edu\/linuspaulinginstitute\/files\/2016\/02\/DOH-Heart-300x266.png?resize=350%2C200","width":350,"height":200},"classes":[]},{"id":813,"url":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/2014\/02\/27\/micronutrients\/","url_meta":{"origin":1118,"position":1},"title":"What is a Micronutrient?","author":"Alexander Michels, PhD","date":"February 27, 2014","format":false,"excerpt":"The Linus Pauling Institute likes to use\u00a0the word micronutrient. This is not only because many world-renown authorities on micronutrients work at the LPI, but also because we maintain a database of scientifically accurate information regarding the roles of micronutrients in human health and disease, the Micronutrient Information Center (MIC). Exactly\u2026","rel":"","context":"In "Ask the Expert"","block_context":{"text":"Ask the Expert","link":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/category\/ask-the-expert\/"},"img":{"alt_text":"micronutrient","src":"https:\/\/i0.wp.com\/blogs.oregonstate.edu\/linuspaulinginstitute\/files\/2013\/10\/micronutrient-300x187.png?resize=350%2C200","width":350,"height":200},"classes":[]},{"id":1809,"url":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/2016\/07\/27\/questions-vitamin-d\/","url_meta":{"origin":1118,"position":2},"title":"Vitamin D Webinar with Dr. Adrian Gombart","author":"Alexander Michels, PhD","date":"July 27, 2016","format":false,"excerpt":"Adrian Gombart, Ph.D. is the resident expert on vitamin D at the Linus Pauling Institute.","rel":"","context":"In "Ask the Expert"","block_context":{"text":"Ask the Expert","link":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/category\/ask-the-expert\/"},"img":{"alt_text":"Adrian Gombart, PhD - Expert on Vitamin D","src":"https:\/\/i0.wp.com\/blogs.oregonstate.edu\/linuspaulinginstitute\/files\/2016\/07\/gombart1.jpg?resize=350%2C200","width":350,"height":200},"classes":[]},{"id":955,"url":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/2014\/03\/04\/taking-multivitamins-still-good-idea\/","url_meta":{"origin":1118,"position":3},"title":"Taking multivitamins – still a good idea.","author":"Alexander Michels, PhD","date":"March 4, 2014","format":false,"excerpt":"A recent\u00a0report from the US Preventive Services Task Force in the Annals of Internal Medicine focused on the use of vitamin, mineral, or multivitamin supplements.\u00a0Their conclusions are that the current evidence is insufficient to assess the benefits and harms of these\u00a0supplements with respect to prevention of cardiovascular disease and cancer.\u2026","rel":"","context":"In "Ask the Expert"","block_context":{"text":"Ask the Expert","link":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/category\/ask-the-expert\/"},"img":{"alt_text":"Multivitamins","src":"https:\/\/i0.wp.com\/blogs.oregonstate.edu\/linuspaulinginstitute\/files\/2014\/03\/Multivitamins2.png?resize=350%2C200","width":350,"height":200},"classes":[]},{"id":970,"url":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/2015\/09\/04\/fish-oil-good-health\/","url_meta":{"origin":1118,"position":4},"title":"Fish oil: Good for my health… or not?","author":"Giana Angelo","date":"September 4, 2015","format":false,"excerpt":"Stories from various news outlets (and even from different researchers at Oregon State University) have said: Fish oil\/omega-3s are great! Excess omega-3s are really bad! Fish oil\/omega-3s are great\u00a0(again)!! Never mind,\u00a0fish oil doesn\u2019t work... This is confusing and frustrating for all of us. 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The\u00a0best and most comprehensive analysis of\u2026","rel":"","context":"In "LPI Take"","block_context":{"text":"LPI Take","link":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/category\/lpi-take\/"},"img":{"alt_text":"Woman with Cold","src":"https:\/\/i0.wp.com\/osu-wams-blogs-uploads.s3.amazonaws.com\/blogs.dir\/1431\/files\/2015\/02\/disease-4392149_640-300x200.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]}],"_links":{"self":[{"href":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/wp-json\/wp\/v2\/posts\/1118","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/wp-json\/wp\/v2\/users\/5337"}],"replies":[{"embeddable":true,"href":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/wp-json\/wp\/v2\/comments?post=1118"}],"version-history":[{"count":15,"href":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/wp-json\/wp\/v2\/posts\/1118\/revisions"}],"predecessor-version":[{"id":1680,"href":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/wp-json\/wp\/v2\/posts\/1118\/revisions\/1680"}],"wp:attachment":[{"href":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/wp-json\/wp\/v2\/media?parent=1118"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/wp-json\/wp\/v2\/categories?post=1118"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dev.blogs.oregonstate.edu\/linuspaulinginstitute\/wp-json\/wp\/v2\/tags?post=1118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}