Chances are that you, or someone you know, has had lower back pain get in the way of daily life. For some people it is merely an inconvenience, but for many, it is debilitating. In the United States, over 70% of adults suffer from back pain at some time during their lives. Lower back pain is the second-most common reason for missed work, after the common cold. Lost productivity due to lower back pain is estimated to be over $30 billion dollars annually.

Out of the myriad causes of lower back pain, one of the most common is degeneration of the intervertebral disk. The intervertebral disk is like a shock absorber between bones in the spine. As people age, wear-and-tear on these disks leads to damage: essentially only children have intervertebral disks without any signs of deterioration. By middle age, lower back pain is sometimes bad enough that people resort to invasive surgeries.

Ward presenting his research at the Graduate Research Showcase, 2019.

Ward Shalash, a first-year PhD student studying bioengineering with Dr. Morgan Giers, is working to find a better way to treat deteriorated intervertebral disks. Currently, the primary method for treating severe back pain caused by a deteriorated intervertebral disk is to either replace the disk with an artificial disk, or to remove the disk and fuse the neighboring vertebra. Although these methods are effective in relieving pain, patients often need to have the procedure redone after ten years. In addition, particularly for the method where vertebra are fused, patients experience loss of flexibility. In 2003 a new method, cell replacement therapy, was demonstrated on a rabbit. This treatment involves collecting mesenchymal stem cells from a patient (generally from fat cells), and injecting them into the gel-like material in the center of the intervertebral disk. Ideally, this process allows the disk to be restored in place. While this treatment has been applied with some success to human patients, the procedure is not yet standardized or tested well enough for FDA approval in the US. In particular it isn’t yet clear how to determine the number of cells to inject for best results.

This is where Ward’s research comes in. “The goal is to develop a method so that doctors can know whether cell replacement therapy will work for patients or not,” said Ward. An intervertebral disk consists of three main parts: the nucleous puplosus, a jelly-like substance in the center; the anulus fibrosus, stiff, fibrous walls around the jelly center; and cartilage endplates above and below.

Cross-section of an intervertebral disk. As the disk deteriorates, the gel-like nucleus pulposus leaks into the fibers of the anulus fibrosus.

Cells require a supply of nutrients to survive; as there is no blood flow into the disk, cells inside rely on water seeping through the cartilage endplates. Dissolved in the water are nutrients such as glucose and oxygen which are vital for cell survival.

Ward uses a combination of MRI imaging and mathematical modeling to study the flow of water through the intervertebral disk. From this information, he hopes to find a method doctors can use to determine the number of stem cells to inject. Ward hopes that the ability to algorithmically predict the success of treatment this way would cut down the cost of clinical trials.

Ward’s parents at the commencement ceremony in 2018. As a first-generation college student Ward mentions that his family’s support was important for him to continue his education towards a PhD degree.

Ward first came to Oregon as an exchange student from Israel. After finishing an associate’s degree at Portland Community College, he came to Oregon State to study bioengineering. He has a dream of a world where people don’t have to worry about injuries. One of his concerns is making sure that progress in bioengineering is ethical.  For example, says Ward, “How do you make sure that it’s accessible for all kinds of people?”

Along with his academic pursuits, Ward enjoys the outdoors, playing the oud, and volunteering. To hear more about Ward’s story and his science, tune in this Sunday at 7PM (PST). You can stream the show live online, or listen to the interview live on the air at 88.7 KBVR FM, Corvallis. If you miss the broadcast, you can also listen to the episode on our podcast soon after the broadcast.

In the background is Mt. Broken Top in the Deschutes Basin. Despite common belief that PhD degrees are scary and stressful, Ward believes that there is always time for adventures!

References:
Summary of stem cell treatment for back pain: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347696/
Discussion of current strategies for treatment of lower back pain: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651638/

Jason at the whiteboard

Consider the language and messages you process each day. As you navigate your daily routine, what language do you hear and see most frequently? For folks living in the Corvallis, Oregon, the answer is probably English. In the last month, how many times, when, and where have you been exposed to spoken words or even signs in another language? For those of us on the Oregon State University campus, you could easily overhear or may participate in a conversation in Spanish, Chinese, or Arabic in the Memorial Union or Valley Library. How does the “linguistic landscape” (written or spoken words you encounter in life) affect you? What do you feel and how do you react to hearing a language you don’t understand? Have you been told that you don’t speak English well enough?

Shenanigans in Portland with Pat

Jason Sarkozi-Forfinski, a PhD student in Anthropology, wants to gain insight into the linguistic landscape students at Oregon State University are exposed to and their actions and feelings about about it, especially for students from non-English speaking countries. Jason’s research involves interviewing students and community members about their experiences in the US such as:

• How do Thai-speaking folks fair when practicing English with a non-American accent?
• How does a (white) American- English speaker from Roseburg regard different accents?
• How do Mandarin speakers from Malaysia react to others speaking English with different accents?
• How does an Arabic speaker from the Gulf region perceive their own accent?
• How comfortable do Japanese speakers feel speaking a language other than English in the US?
• How is all of this connected to the institutionalized tool of racism?

Jason has found that folks have preferences or biases about their linguistic landscape. Oregon State recruits both students from around the world and a large multilingual community of more local students. His respondents have reported being discouraged from speaking in a non-English language or facing negative social and professional consequences for speaking other languages or English with a non-(white)American accent. Could a preference for English with a (white) American accent perpetuate division? Or even bigoted practices?

Jason’s current research developed from years of conversations with friends and colleagues about being multilingual in the US. He began exploring language in his undergraduate education where he majored in Spanish and also studied Portuguese. He also studied English in Miami,

Grilled cheese on a school bus in Portland with Veronica (left) and husband, Nick.

Florida, and worked to understand how non-English languages influences local English. Before coming to OSU for his PhD, Jason has worked as a Spanish and English instructor in the US, Spain, Japan, and China.

Tune in to KBVR Corvallis 88.7 FM on Sunday March, 10 at 7 PM to hear more about Jason’s research and his path to graduate school. Stream the show live or catch this episode as a podcast.

Clarification [See Podcast at 25:45]: Asking someone to change their accent, according to Lippi-Green a linguistic who wrote “Speaking with an Accent,” is like asking someone to change their height. It’s doable (with lots of surgery) but would require a lot of intervention. The point here is that it’s not realistic to ask someone to work on their accent. It’s also rather demeaning.

Summary: Graduate student researchers Brian Erickson and Chelsea Behymer talk about their transition from natural sciences to social sciences and the process of finding their place within their disciplines.

As graduate students, many of our academic conversations focus around our research. But graduate school is about more than just designing and carrying out a project; it also involves finding your place within a larger community.

Chelsea Behymer and Brian Erickson met through a science communication course in the Integrative Biology department (IB599), and they quickly found common ground. Although their research interests are very different, both have had experiences that sparked interest and conviction to explore the human dynamic of the ecological systems with which they are more familiar. While neither is new to academia, they find themselves navigating new identities as they explore what it means to be a social scientist working on human components of environmental issues.

Chelsea takes guests onboard a coastal Alaskan expedition on an intertidal walk.

Chelsea is a first-year Ph.D student in the Environmental Sciences graduate program, with a focus on informal science education. For the past six years, Chelsea has engaged diverse groups of people in marine biology and natural history as a Naturalist onboard both large and smaller, expedition style cruise ships. Interacting with a diversity of people in shared travel and learning experiences across the world’s oceans has been one of the most rewarding roles of her career. At the same time, being immersed in nature-based tourism has opened her eyes to the nature-based tourism industry as not only a place where human connections to the natural world are fostered, but provides wonderful opportunities for science communication.

With the growing nature-based tourism industry, perhaps the opportunities to connect have never been more abundant. Chelsea’s research interests aim to understand the potential for citizen science in nature-based tourism to act as both an effective means of engaging people with local scientists, while at the same time providing opportunities for the kind of collaborative environment where meaningful conversations between scientists and the public can occur.

Brian presents work on ocean acidification education during the State of the Coast conference.

Brian is also a first-year Ph.D student studying fisheries social science in the Department of Fisheries and Wildlife. Growing up in the midwest, he first fell in love with the ocean while working as a field technician in the US Virgin Islands, Panama, and the Northwest Hawaiian islands. Partially because he defined himself as a biologist, it took him almost a decade to realize that he was interested in answering social science questions. Brian is generally interested in applying what we know about human behavior to improve marine conservation outcomes for people and the planet. His master’s work at OSU focused on exploring a commonly held assumption – that knowledge of environmental problems leads to action to fix those problems – through the lens of a high school ocean acidification curriculum. For his PhD work, Brian will be collaborating with the SMART Seas Africa Programme to examine social aspects of marine conservation in East Africa.

In this special segment, Chelsea and Brian will talk with ID host Kristen Finch about the challenge of finding their way as social scientists in a field that is working towards interdisciplinary collaboration. Don’t miss this conversation; tune in to KBVR Corvallis 88.7FM at 6 pm PST on Sunday March, 10. Stream the show live or catch the podcast.

Written by Chelsea Behymer and Brian Erickson. Edited by Kristen Finch.

Hey guys, do you notice when you or others use gendered language? As with the last sentence, gendered language has become part of our culture’s vocabulary and we may use it without a second thought. There is a growing field of research that studies how language can shape perceptions of ourselves and others.

Jeana presenting “Decolonizing Masculinities” with Nyk Steger and Minerva Zayas at the 2018 Examining Masculinities Conference at OSU

Jeana Moody is a second year Masters student in Women, Gender and Sexuality Studies working with Professor Bradley Boovy. Her thesis research focuses on the use and impact of gendered words and phrases in the English language, such as “throw like a girl”, “man up”, and “don’t be a bitch.” What are the implications of saying “man up” to someone who presents as a woman? As a man? Does the gender of the speaker play a role?

To explore this, Jeana designed a study to collect data through in-person interviews and anonymous online surveys, asking participants to describe situations when they have either used such statements or have been the subject of the statements. The questions include: where did this happen? Who was there? Were there any power dynamics? How did it make you feel then, and now?

For any research involving human participants, OSU researchers must submit a proposal to and be approved by Oregon State’s Institutional Review Board (IRB). This rigorous process requires submission of interview questions, the number of participants, how the data will be collected, and how consent will be obtained from the participants. Additionally, since there is always the possibility of triggering a participant’s traumatic memories from survey questions, help resources must be provided to participants. Jeana’s study was just approved last week.

Jeana hiking in the San Gabriel Mountains in Southern California

From the data collected, Jeana hopes to gain insight into feelings of and implications on participants in the study, and present the anecdotal evidence within a cultural context. This research draws from the subjects of feminist sociolinguistics and critical race theory. It addresses the idea that language begets culture, and culture begets language. Her interest in the subject arose from working with non-native English speakers. She observed that they often use American swear words and racist words without understanding the impact of the words they were using. Just because someone doesn’t understand those words doesn’t mean they don’t hold an impact.

Jeana hiking in the Willamette National Forest in Oregon

When Jeana is not conducting research, she is the instructor of record for Men and Masculinities and is a Teaching Assistant for several other classes. She is originally from Pullman, Washington and attended Western Washington University as part of the Fairhaven College (an interdisciplinary liberal arts college). She enjoys hiking and being anywhere outdoors, and she loves to cook and draw. When not in Corvallis, she can likely be found in Prague where she has taught English and worked for a travel agency.

If you are interested in participating in Jeana’s research study online or in-person, please email moodyje@oregonstate.edu to set up an interview or with any questions you may have, or follow the link to her Gendered Language Online Survey.

Written by Maggie Exton.

While Senecio triangularis, native to Western Oregon, was not the intended hostplant of the introduced cinnabar moth, it has been supporting moth populations for decades.

Invaded places are not broken spaces

“It was some of the hardest work I have done,” says this week’s guest, Katarina Lunde recounting her arduous work interning with the Nature Consortium in the Duwamish region of Seattle. Katarina was passionate about her work in conservation ecology, spending countless hours leading groups of volunteers in restoration projects and educating the community about the restoration sites. But it was somewhere in the bone-chilling cold tearing out invasive species like the Himalayan blackberry and English ivy that Katarina had a shift in perception – these spaces were not broken. Katarina realized that informed decisions could tip the scales in the right direction in these vulnerable spaces. There was still hope to be found in the midst of these invasions. The desire to study ecology more deeply led Katarina to pursue a master’s degree in plant ecology with Dr. Peter McEvoy in the Department of Botany and Plant Pathology at Oregon State University.

Learning to tip the scales

In the 1920s, tansy ragwort (Senecio jacobaea) was first observed in the Portland, Oregon. This introduced, noxious weed, was causing severe liver failure and even death for grazing cattle and deer. The major economic implications on livestock prompted the Oregon Department of Agriculture to intervene. By the 1960s, the cinnabar moth (Tyria jacobaeae) was released as one of three insect biological control agents. The role of the cinnabar moth was to reduce tansy ragwort populations by depositing their eggs on the underside of the leaf and allowing newly hatched caterpillars to feed on and eventually kill the plant. However, there was an unintended consequence. When these very hungry caterpillars were released in the mountainous Cascade region, they found that a closely-related native plant species, arrowleaf groundsel (Senecio triangularis), was also quite appetizing.

Cinnabar caterpillars strip late-season Senecio triangularis stems of foliage. Luckily, most plants will have set seed and stored energy before the caterpillars reach peak feeding stages.

Despite this outcome, the release of the cinnabar moth has been largely viewed as a success, even though this biocontrol agent likely would not have been released under current standards. This system does then provide an ideal model system to identify long-term risks and benefits of biocontrol use. When it comes to biological invasions, the cost of inaction is often too high, so what are the risks and benefits?

Katarina Lunde installs experimental plots at a field site with the help of fellow lab members. She measured Senecio triangularis seedling recruitment under seed addition/reduction scenarios to assess potential impacts of seed loss due to cinnabar moth herbivory.

By studying seed loss and plant recruitment – do more seeds equal more plants? – on Marys Peak in Oregon’s coastal range, Katarina has been able to assess the risk that cinnabar moths pose on native plant survival. The answers are nuanced, of course, as this deals with a dynamic natural system, but Katarina’s work is allowing for better questions to be asked that will in turn better inform decision making regarding biological controls.

Finding the perfect fit

Katarina studied plants and plant systematics at Oberlin College where she obtained a bachelor’s degree in biology and creative writing. With student loans to pay off and a desire to find a career that fit her unique abilities and interests, Katarina spent six years working in fine dining and exploring future career paths in Seattle, WA, volunteering with various non-profits. Through her restoration program internship with the Nature Consortium, she was finally able to hone-in on the field of plant ecology. Katarina is currently nearing the end of her master’s program and seeks to apply her newly learned skills in an urban conservation and restoration setting, where she can continue to ask questions and interact with her work in a tangible way.

Katarina’s research has been supported by a NIFA grant and several awards from agencies that focus on native plant restoration and conservation, including: the Hardman Foundation Award, the Native Plant Society of Oregon, and the Portland Garden Club.

Join us on Sunday, November 18 at 7 PM on KBVR Corvallis 88.7 FM or stream live to learn more about the nuance of biological controls and Katarina’s journey to graduate school.