{"id":9335,"date":"2018-05-22T15:26:56","date_gmt":"2018-05-22T22:26:56","guid":{"rendered":"http:\/\/blogs.oregonstate.edu\/impact\/?p=9335"},"modified":"2018-05-22T15:32:08","modified_gmt":"2018-05-22T22:32:08","slug":"blood-schizophrenia-patients-contains-genetic-material-microbes","status":"publish","type":"post","link":"https:\/\/dev.blogs.oregonstate.edu\/impact\/2018\/05\/blood-schizophrenia-patients-contains-genetic-material-microbes\/","title":{"rendered":"The blood of schizophrenia patients contains more genetic material from microbes"},"content":{"rendered":"

The blood of schizophrenia patients features genetic material from more types of microorganisms than that of people without the debilitating mental illness, based on new research by mathematical biologist David Koslicki<\/a> as part of an international\u00a0collaboration.<\/p>\n

Scientists at UCLA, the University of California-Davis, the University of California-San Francisco, University Medical Center Utrecht and Wageningen University collaborated on the study, the first to use unmapped non-human reads to assess the microbiome from whole blood.<\/p>\n

What\u2019s not known is whether that\u2019s a cause or effect of the severe, chronic condition that strikes about one person in 100.<\/p>\n

\u201cIt’s a common assumption that healthy blood is sterile so some may find it surprising that we even found bacterial genetic material in the bloodstream,\u201d said Koslicki, an assistant professor of mathematics in the College of Science.<\/p><\/blockquote>\n

Koslicki and collaborators performed whole-blood transcriptome analyses on 192 people, including healthy\u00a0people\u00a0as well as those with schizophrenia, bipolar disorder and amyotrophic lateral sclerosis (ALS), or Lou Gehrig\u2019s disease. The findings were published in Translational Psychiatry<\/em><\/a> last week.<\/p>\n

Transcriptome analysis refers to the sequencing of ribonucleic acid, or RNA. RNA works with DNA, the other nucleic acid \u2013 so named because they were first discovered in the cell nuclei of living things \u2013 to produce the proteins needed throughout an organism.<\/p>\n

Studying the blood samples, researchers detected RNA from a range of bacteria and archaea \u2013 with the range wider for schizophrenics than for the other three groups.<\/p>\n

\u201cMore and more we know the human microbiome plays a huge role in health and disease,\u201d Koslicki said.<\/p><\/blockquote>\n

\u201cGut bacteria account for most of the trillions of microbial cells in the human body, and this study shows that microbiota in the blood are similar to ones in the mouth and gut. It appears there\u2019s some sort of permeability there into the bloodstream. Down the road, microscopy, culturing or direct measures of permeability may be able to shed light on that.\u201d<\/p>\n

\"\"<\/p>\n

The researchers found schizophrenics\u2019 blood samples were more likely to contain two phyla in particular \u2013 Planctomycetes and Thermotogae \u2013 but the overall results suggest it\u2019s unlikely those are the sole reason for the elevated microbial diversity.<\/p>\n

Scientists also found fewer of the immunity-enhancing CD8+ memory T cells in the blood of schizophrenics.<\/p>\n

\u201cThat could suggest a mechanism for why we see increased microbial diversity in the blood, and it\u2019s also possibly affected by lifestyle or health status differences between schizophrenia patients and the other groups,\u201d Koslicki said.<\/p>\n

\u201cIn addition, it\u2019s interesting that bipolar disorder, which is genetically and clinically correlated to schizophrenia, didn\u2019t show a similar increased microbial diversity.\u201d<\/p>\n

Koslicki also notes that the RNA sequencing can\u2019t detect if microbes are actually living in the blood, only that their genetic material is there; it could have gotten there from somewhere else in the body.<\/p>\n

The National Institutes of Health, the National Institute of Mental Health and the National Science Foundation supported this research.<\/p>\n","protected":false},"excerpt":{"rendered":"

The blood of schizophrenia patients features genetic material from more types of microorganisms than that of people without the debilitating mental illness.<\/p>\n","protected":false},"author":5667,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[643004,712346,641666,523],"tags":[646150],"class_list":["post-9335","post","type-post","status-publish","format-standard","hentry","category-big-data","category-biohealth-science","category-mt","category-research","tag-author-debbie-farris"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p6vHeb-2qz","jetpack-related-posts":[{"id":4372,"url":"https:\/\/dev.blogs.oregonstate.edu\/impact\/2016\/07\/genetic-code-expansion-conference\/","url_meta":{"origin":9335,"position":0},"title":"Genetic 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