{"id":11040,"date":"2019-04-04T13:39:28","date_gmt":"2019-04-04T20:39:28","guid":{"rendered":"http:\/\/blogs.oregonstate.edu\/impact\/?p=11040"},"modified":"2019-04-04T14:12:01","modified_gmt":"2019-04-04T21:12:01","slug":"liver-colon-cancer-cells-thwarted-by-compounds-derived-from-hops","status":"publish","type":"post","link":"https:\/\/dev.blogs.oregonstate.edu\/impact\/2019\/04\/liver-colon-cancer-cells-thwarted-by-compounds-derived-from-hops\/","title":{"rendered":"Liver, colon cancer cells thwarted by compounds derived from hops"},"content":{"rendered":"
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The plant that adds flavor, color and bitterness to beer also produces a primary compound that thwarts cancer cells, and two important derivatives of the compound do as well, new research by biochemist Adrian Gombart<\/a> shows.<\/p>\n

Unlike the primary compound, xanthohumol, known as XN, the derivatives don\u2019t metabolize into phytoestrogens. Phytoestrogens are plant-based chemicals similar to female sex hormones that help some types of tumors grow and can cause other health problems as well.<\/p>\n

The research showed, for the first time, that the derivatives have cancer-fighting effectiveness similar to that of XN in liver and colon carcinomas. That means the two non-estrogenic derivatives are attractive alternatives for testing, along with XN, in future preclinical studies..<\/p>\n

The study was published in the International Journal of Molecular Sciences.<\/p>\n

Xanthohumol is produced by humulus lupulus, the common hop plant. More than 20 years ago, researchers discovered that XN inhibits cell growth in a variety of cancer cell lines.<\/p>\n

\u201cBut a potential problem with XN is that enzymes in the liver and the gut microbiota metabolize it into 8- prenylnaringenin, or 8-PN, the most potent phytoestrogen known,\u201d said Gombart, a principal investigator at OSU\u2019s Linus Pauling Institute.<\/p>\n

The derivatives that don\u2019t metabolize into 8-PN are DXN, short for dihydroxanthohumol, and TXN, which refers to tetrahydroxanthohumol.<\/p>\n

Earlier, Gombart\u2019s Linus Pauling Institute colleague and co-author Fred Stevens led a study into DXN and TXN\u2019s effects on metabolic syndrome.<\/p>\n

\u201cIn that previous research we showed that the two derivatives reduced weight gain and improved biomarkers of metabolic syndrome,\u201d Gombart said. \u201cXN had been shown to inhibit proliferation of a variety of cancer cell lines, and in this study, we demonstrated XN\u2019s ability to halt cell growth and kill two liver cancer cell lines and two colon cancer cell lines. We tested liver and colon cancer cell lines because oral consumption of XN and its derivatives can lead to high concentrations in the gut and liver.\u201d<\/p>\n

Colorectal cancer is the third most common cause of cancer-related death in the United States, and liver cancer ranks fifth. The incidence of liver cancer, though, has tripled in the last four decades.<\/p>\n

\u201cFor both of those cancers, discovering new compounds for prevention and treatment is imperative,\u201d Gombart said. \u201cIn all the cell lines tested, DXN and TXN inhibited cell growth and caused cell death, as did XN. And for most cell types, DXN and TXN were slightly more potent.\u201d<\/p>\n

Supporting the research were the National Center for Complementary and Integrative Health at the National Institutes of Health; Hopsteiner Inc.; the Buhler-Wang Research Fund; the OSU Department of Biochemistry and Biophysics; and the Linus Pauling Institute.<\/p>\n

Collaborating with Gombart were OSU colleagues Stevens, Isabelle Logan, Cristobal Miranda, Malcolm Lowry and Claudia Maier.<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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About the Linus Pauling Institute:<\/strong>\u00a0The Linus Pauling Institute at OSU is a world leader in the study of micronutrients and their role in promoting optimum health or preventing and treating disease. Major areas of research include heart disease, cancer, aging and neurodegenerative disease.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

The hops plant produces a compound that thwarts cancer cells, and two key derivatives of the compound are even more effective.<\/p>\n","protected":false},"author":8299,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[640488,712346,1507,523],"tags":[712392,1733],"class_list":["post-11040","post","type-post","status-publish","format-standard","hentry","category-bb","category-biohealth-science","category-faculty-and-staff","category-research","tag-author-katharine-de-baun","tag-healthy-people"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p6vHeb-2S4","jetpack-related-posts":[{"id":5072,"url":"https:\/\/dev.blogs.oregonstate.edu\/impact\/2016\/10\/biochemistry-professor-makes-new-discoveries-age-related-decline\/","url_meta":{"origin":11040,"position":0},"title":"Biochemistry 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